Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ssr2_human 196 ECL2 N => ThrfsTer40 frameshift 8.358e-06 1 119648 0 None None
ssr2_human 241 ICL3 R => Ter stop gained 8.245e-06 1 121284 0 None None
ssr2_human 256 6.35x35 TM6 R => Ter stop gained 8.237e-06 1 121406 0 None None
ssr2_human 353 C-term T => LysfsTer? frameshift 6.055e-05 1 16514 0 None None PTM (Phosphorylation)
ssr2_human 3 N-term M => T missense 9.506e-06 1 105202 0 0.48 0.001
ssr2_human 4 N-term A => V missense 1.891e-05 2 105768 0 0.29 0.002
ssr2_human 5 N-term D => N missense 9.308e-06 1 107432 0 0.28 0.001
ssr2_human 12 N-term H => Y missense 8.83e-06 1 113254 0 1.0 0.013
ssr2_human 21 N-term L => F missense 1.692e-05 2 118194 0 0.82 0.004
ssr2_human 23 N-term G => D missense 8.383e-06 1 119296 0 0.6 0.002
ssr2_human 25 N-term V => G missense 8.32e-06 1 120190 0 0.41 0.0
ssr2_human 26 N-term V => L missense 1.662e-05 2 120356 0 0.84 0.001
ssr2_human 27 N-term S => L missense 0.0003731 45 120618 1 0.37 0.001
ssr2_human 31 N-term S => A missense 8.261e-06 1 121054 0 0.1 0.228
ssr2_human 36 N-term P => T missense 8.247e-06 1 121258 0 0.27 0.008
ssr2_human 36 N-term P => L missense 1.649e-05 2 121286 0 0.2 0.005
ssr2_human 39 N-term D => H missense 8.241e-06 1 121342 0 0.12 0.885
ssr2_human 48 1.37x37 TM1 F => L missense 8.238e-06 1 121390 0 1.0 0.017
ssr2_human 51 1.40x40 TM1 F => V missense 8.238e-06 1 121396 0 0.24 0.853
ssr2_human 52 1.41x41 TM1 V => M missense 1.647e-05 2 121400 0 0.09 0.06
ssr2_human 56 1.45x45 TM1 I => T missense 8.237e-06 1 121404 0 0.01 0.321
ssr2_human 69 1.58x58 TM1 L => F missense 8.237e-06 1 121410 0 0.03 0.787
ssr2_human 70 1.59x59 TM1 R => C missense 5.766e-05 7 121410 0 0.02 0.998
ssr2_human 70 1.59x59 TM1 R => H missense 2.471e-05 3 121410 0 0.07 0.996
ssr2_human 78 2.39x39 TM2 T => I missense 8.236e-06 1 121412 0 0.0 1.0
ssr2_human 87 2.48x48 TM2 I => V missense 1.647e-05 2 121412 0 0.82 0.16
ssr2_human 88 2.49x49 TM2 A => T missense 5.765e-05 7 121412 0 0.01 1.0
ssr2_human 101 2.62x62 TM2 M => V missense 8.237e-06 1 121406 0 0.4 0.002
ssr2_human 106 ECL1 V => A missense 8.237e-06 1 121408 0 0.56 0.026
ssr2_human 116 3.26x26 TM3 R => W missense 2.471e-05 3 121404 0 0.0 1.0
ssr2_human 116 3.26x26 TM3 R => Q missense 8.238e-06 1 121394 0 0.01 0.94
ssr2_human 117 3.27x27 TM3 V => M missense 8.237e-06 1 121402 0 0.05 0.465
ssr2_human 121 3.31x31 TM3 V => A missense 0.0003954 48 121402 0 0.17 0.221
ssr2_human 125 3.35x35 TM3 N => D missense 8.237e-06 1 121402 0 0.0 1.0
ssr2_human 132 3.42x42 TM3 C => Y missense 8.237e-06 1 121402 0 0.0 0.986
ssr2_human 139 3.49x49 TM3 D => N missense 8.237e-06 1 121404 0 0.0 1.0 SodiumPocket MicroSwitch
ssr2_human 148 34.51x51 ICL2 I => T missense 1.647e-05 2 121404 0 0.13 0.887 GP (contact)
ssr2_human 150 34.53x53 ICL2 S => L missense 1.647e-05 2 121404 0 0.0 0.978 GP (contact)
ssr2_human 157 4.40x40 TM4 R => Q missense 3.295e-05 4 121398 0 0.28 0.261
ssr2_human 158 4.41x41 TM4 T => M missense 8.237e-06 1 121400 0 0.04 0.029
ssr2_human 161 4.44x44 TM4 M => I missense 1.648e-05 2 121394 0 0.53 0.012
ssr2_human 164 4.47x47 TM4 M => L missense 1.648e-05 2 121388 0 0.7 0.001
ssr2_human 164 4.47x47 TM4 M => T missense 8.238e-06 1 121386 0 0.21 0.007
ssr2_human 164 4.47x47 TM4 M => I missense 8.239e-06 1 121380 0 0.24 0.004
ssr2_human 177 4.60x61 TM4 I => V missense 1.651e-05 2 121110 1 1.0 0.25 LB (hydrophobic, Van der Waals)
ssr2_human 180 4.63x64 TM4 Y => H missense 8.271e-06 1 120898 0 0.0 0.907
ssr2_human 183 ECL2 L => P missense 8.291e-06 1 120618 0 0.0 0.1
ssr2_human 184 ECL2 R => W missense 8.298e-06 1 120516 0 0.03 0.764
ssr2_human 184 ECL2 R => Q missense 8.299e-06 1 120494 0 0.67 0.004
ssr2_human 190 ECL2 R => G missense 8.328e-06 1 120080 0 0.48 0.005
ssr2_human 194 45.51x51 ECL2 T => N missense 8.35e-06 1 119756 0 1.0 0.09 LB (polar (hydrogen bond), Van der Waals)
ssr2_human 197 ECL2 W => C missense 1.673e-05 2 119548 0 0.01 0.989
ssr2_human 198 ECL2 P => T missense 5.023e-05 6 119440 0 0.0 1.0
ssr2_human 199 ECL2 G => A missense 8.374e-06 1 119412 0 0.04 0.273
ssr2_human 203 5.33x34 TM5 A => V missense 1.679e-05 2 119112 0 1.0 0.021
ssr2_human 207 5.37x38 TM5 G => A missense 3.36e-05 4 119044 0 1.0 0.035
ssr2_human 207 5.37x38 TM5 G => V missense 8.4e-06 1 119044 0 0.57 0.075
ssr2_human 214 5.44x45 TM5 I => T missense 1.68e-05 2 119028 0 0.74 0.34
ssr2_human 226 5.56x56 TM5 L => F missense 7.493e-05 9 120116 0 0.01 0.805
ssr2_human 226 5.56x56 TM5 L => V missense 8.325e-06 1 120116 0 0.01 0.092
ssr2_human 232 5.62x62 TM5 I => V missense 1.655e-05 2 120838 0 1.0 0.25
ssr2_human 240 ICL3 I => N missense 1.649e-05 2 121276 0 0.15 0.179
ssr2_human 241 ICL3 R => Q missense 8.244e-06 1 121304 0 0.01 0.693
ssr2_human 242 ICL3 V => A missense 2.473e-05 3 121322 0 0.91 0.132
ssr2_human 250 6.29x29 TM6 S => C missense 8.237e-06 1 121400 0 0.0 0.996 GP (contact)
ssr2_human 254 6.33x33 TM6 V => A missense 8.237e-06 1 121408 0 0.04 0.994 GP (contact)
ssr2_human 259 6.38x38 TM6 S => P missense 8.237e-06 1 121406 0 0.01 0.973
ssr2_human 260 6.39x39 TM6 I => T missense 8.237e-06 1 121408 0 0.05 0.019
ssr2_human 266 6.45x45 TM6 I => L missense 8.237e-06 1 121408 0 0.03 0.162
ssr2_human 266 6.45x45 TM6 I => V missense 8.237e-06 1 121408 0 1.0 0.012
ssr2_human 274 6.53x53 TM6 I => M missense 8.236e-06 1 121412 0 0.11 0.885
ssr2_human 275 6.54x54 TM6 F => V missense 8.236e-06 1 121412 0 0.84 0.975 LB (hydrophobic, aromatic (edge-to-face), Van der Waals)
ssr2_human 277 6.56x56 TM6 V => D missense 8.236e-06 1 121412 0 0.0 0.981
ssr2_human 280 6.59x59 TM6 V => I missense 3.295e-05 4 121412 0 0.1 0.742 LB (Van der Waals, hydrophobic, polar (hydrogen bond with backbone))
ssr2_human 282 6.61x61 TM6 M => I missense 0.0002553 31 121412 0 0.38 0.001
ssr2_human 290 7.31x30 TM7 L => I missense 8.236e-06 1 121412 0 0.14 0.426 LB (Van der Waals, hydrophobic, polar (hydrogen bond with backbone))
ssr2_human 292 7.33x32 TM7 G => V missense 1.647e-05 2 121412 0 0.03 0.637
ssr2_human 295 7.36x35 TM7 D => A missense 8.236e-06 1 121412 0 0.5 0.049 LB (polar (charge-assisted hydrogen bond))
ssr2_human 297 7.38x37 TM7 V => L missense 8.236e-06 1 121412 0 0.12 0.477
ssr2_human 298 7.39x38 TM7 V => A missense 8.236e-06 1 121412 0 0.0 0.887 LB (hydrophobic, Van der Waals)
ssr2_human 307 7.48x48 TM7 A => T missense 1.647e-05 2 121412 0 0.02 0.991
ssr2_human 309 7.50x50 TM7 P => S missense 8.237e-06 1 121410 0 0.0 1.0 SodiumPocket MicroSwitch
ssr2_human 313 7.54x54 TM7 A => V missense 1.647e-05 2 121412 0 0.02 0.996
ssr2_human 314 7.55x55 TM7 F => S missense 1.647e-05 2 121412 0 0.0 0.999 GP (contact)
ssr2_human 316 8.47x47 H8 S => F missense 1.647e-05 2 121412 0 0.0 0.999 GP (contact)
ssr2_human 318 8.49x49 H8 N => S missense 8.236e-06 1 121412 0 0.02 0.857 GP (contact)
ssr2_human 328 8.59x59 H8 C => W missense 8.237e-06 1 121400 0 0.0 0.996
ssr2_human 330 C-term V => I missense 8.238e-06 1 121388 0 0.42 0.041
ssr2_human 334 C-term G => A missense 8.24e-06 1 121358 0 0.1 0.025
ssr2_human 336 C-term D => Y missense 8.241e-06 1 121344 0 0.01 0.172
ssr2_human 337 C-term D => V missense 8.242e-06 1 121336 0 0.07 0.001
ssr2_human 340 C-term R => W missense 3.298e-05 4 121300 0 0.02 0.654
ssr2_human 340 C-term R => Q missense 4.946e-05 6 121298 0 0.63 0.007
ssr2_human 341 C-term S => T missense 8.246e-06 1 121264 0 0.73 0.002 PTM (Phosphorylation)
ssr2_human 341 C-term S => I missense 8.246e-06 1 121264 0 0.19 0.006 PTM (Phosphorylation)
ssr2_human 341 C-term S => N missense 8.246e-06 1 121264 0 0.48 0.01 PTM (Phosphorylation)
ssr2_human 343 C-term S => N missense 8.25e-06 1 121216 0 0.39 0.006 PTM (Phosphorylation)
ssr2_human 345 C-term Q => K missense 8.256e-06 1 121126 0 0.63 0.007
ssr2_human 345 C-term Q => H missense 8.258e-06 1 121098 0 0.1 0.289
ssr2_human 349 C-term R => Q missense 3.309e-05 4 120894 0 0.12 0.011
ssr2_human 352 C-term E => K missense 8.306e-06 1 120392 0 0.33 0.01
ssr2_human 352 C-term E => D missense 1.661e-05 2 120398 0 0.45 0.003
ssr2_human 353 C-term T => A missense 4.153e-05 5 120396 0 0.92 0.001 PTM (Phosphorylation)
ssr2_human 354 C-term T => M missense 3.326e-05 4 120270 0 0.17 0.011 PTM (Phosphorylation)
ssr2_human 359 C-term T => I missense 8.366e-06 1 119534 0 0.22 0.005 PTM (Phosphorylation)
ssr2_human 367 C-term T => A missense 8.521e-06 1 117356 0 0.01 0.507
ssr2_human 369 C-term I => V missense 2.573e-05 3 116604 0 nan 0.184


Residue

Diagrams

ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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